Astringency is a dry, puckering, rough, or sandpapery sensation in the mouth caused by plant-derived polyphenols. Polyphenols, including flavanols, are well known for risk reduction in cardiovascular ...

A single oral administration of astringent FLs stimulated the central nervous system, activating the hypothalamic coricotropin-releasing hormone (CRH) neurons. The secreted CRH activated the ...