The choice of axons to cross or not to cross the midline of the central nervous system is arguably the best understood of all axon pathfinding decisions 1. Extensive studies of axon pathfinding at the ...
Comm downregulates the Slit receptor Robo on commissural axons, thereby enabling midline crossing. Elegant new experiments show that Comm functions by diverting Robo to the endosomal pathway, ...
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