The central image depicts currently used strategies for clinical targeting of TGF-β. Below are methods applicable from preclinical screening to clinical practice, including using humanized mouse ...

The interplay between host immunity, the microbiota, and cancer is a rapidly evolving area of immuno-oncology. An increasing body of evidence highlights the ...

As multi-cancer early detection (MCED) testing gains momentum, experts are honing their focus on what comes next for patients with a positive MCED test result. Understanding the diagnostic pathways ...

A new hope for those with cancer. Cancer survival rates have reached new heights, with 70% of patients diagnosed hitting the ...

Druggable phosphatases in cancer and immune cells, with examples of their corresponding drugs. Structures of allosteric inhibitors targeting PP2A, PRL3, DUSP1/6, and SHP2 in cancer cells (left).

The researchers used lipid nanoparticles (LNPs) to deliver cyclic GMP-AMP (cGAMP) synthase (cGAS) mRNA to cancer cells. This results in production of the endogenous stimulator of interferon genes ...

Scientists have discovered why ovarian cancer spreads so rapidly through the abdomen. Cancer cells enlist normally protective abdominal cells, forming mixed groups that work together to invade new ...