The inefficiency induced by between-cluster variation in cluster randomized (CR) trials can be reduced by implementing a crossover (CO) design. In a simple CO trial, each subject receives each ...

In this week's PLOS Medicine, Charles Weijer and colleagues present the Ottawa Statement on the Ethical Design and Conduct of Cluster Randomized Trials, which aims to provide researchers and research ...

The authors assessed the effect of provider education and clinical decision support (CDS) on antibiotic prescribing for acute sinusitis. Education and CDS improved antibiotic stewardship and changed ...

Adjuvant Nivolumab in High-Risk Muscle-Invasive Urothelial Carcinoma: Expanded Efficacy From CheckMate 274 In this cluster-randomized clinical trial comparing 174,943 eligible residents in eight towns ...