Complement is a subsystem of immunity that's fast acting and disregulated in multiple inflammatory diseases. Inhibition of complement is a young niche that's gonna get lots more attention soon.

Iptacopan is an innovative, first-in-class oral small molecule that reversibly inhibits factor B—a crucial serine protease in the alternative pathway of the complement system. By targeting this point ...

The fact that the complement system is activated during immune-complex glomerular disease has been known for nearly 50 years. Detection of complement deposition in the glomerulus using immunochemistry ...