The first lineage decisions in mammalian embryonic development are made shortly after a wave of transcriptional activation that acts as a wake-up call for the sleeping embryonic genome to claim the ...

Conditional genetics and single-embryo RNA-seq show that SETDB1 extinguishes the transient, retroelement-driven transcriptional programs of the totipotent two-cell state to facilitate the exit from ...

What do the earliest stages of a pregnancy look like? Embryonic development has been extensively studied, but most of our knowledge of the earliest stages of a growing baby come from stationary ...

Scientists have created a stem cell-derived model of the human embryo in the lab by reprogramming human stem cells. The breakthrough could help research into genetic disorders and in understanding why ...

Nearly half the embryos studied underwent developmental arrest because of genetic mishaps in early development—a revealing insight that suggests more IVF babies could come to term with changes in the ...

Researchers have used stem cells to develop new human embryolike structures that model the earliest stages of fetal development so realistically that they even secrete hormones that can turn a lab ...

A research team showed that, contrary to current models, one early embryonic cell dominates lineages that will become the fetus. “They are not identical,” said Magdalena Zernicka-Goetz, a ...

Using the fruit fly, scientists have constructed a complete and detailed single-cell map of embryo development. This research will also help scientists pursue questions like how mutations lead to ...

Week 3 of pregnancy is a critical stage when the embryo begins to grow rapidly. During this week, cells divide at an astonishing rate, laying the foundation for all future tissues and organs. This ...

For several years, researchers studied human embryonic stem cells (ESCs) to understand the unique features of these pluripotent cells, but on their own, they poorly resembled the complex structures ...