Allison McClure, Ph.D., is an assistant professor in the Department of Biochemistry and Molecular Genetics at the CU School of Medicine. She is focused on learning all about how cells replicate, or ...

The MCM helicase is broadly bound across the genome, and its phosphorylation is antagonistically regulated by the kinase DDK and the phosphatase RIF1–PP1. TRESLIN–MTBP recognises the phosphorylated ...

From The Bedalov Lab, Human Biology and Translational Science and Therapeutics Divisions Thus, the team began this current study with a scavenger hunt for a nucleosome-modifying enzyme which could ...

Single-cell analysis helps uncover how the BK virus replicates, opening the door to new drug targets. BK polyomavirus (BKPyV) is a major cause of kidney transplant failure. Without a complete ...

More than 500,000 people in the United States die each year of cancer-related causes. Now, emerging research has identified the mechanism behind one of the most common mutations that help cancer cells ...

All cells need to sense and respond to their environment—to know when to activate genes, build proteins and carry out their basic functions. One of the most well-studied cellular responses is how they ...