A publication from Acta Pharmaceutica Sinica B discusses the structure-based development of potent and selective type-II kinase inhibitors of RIPK1. Receptor-interacting serine/threonine-protein ...
More than two decades of effort went into a project that has now revealed the structure of a crucial signaling molecule, opening the door to new and better drugs for some cancers. For more than 20 ...
(MEMPHIS, Tenn. – December 18, 2025) Scientists at St. Jude Children’s Research Hospital have characterized a hidden intermediate state at the center of Src kinase function. This hidden state allows ...
Cryo-EM structure of ubiquitous mitochondrial creatine kinase (IMAGE) Sanford Burnham Prebys Caption Scientists at Sanford Burnham Prebys and the Mayo Clinic used cryogenic electron microscopy to ...
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A short-lived kinase state that's essential for normal cell migration and T-cell function
Scientists at St. Jude Children's Research Hospital have characterized a hidden intermediate state at the center of Src kinase function. This hidden state allows the kinase to repeatedly modify its ...
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