Ganji M et al., and Fudenberg G et al., postulated that the SMC family of ATPases, such as condensin and cohesion, extrude DNA into large loops. Energy from ATP hydrolysis helps the SMC proteins to ...

A living cell is able to neatly package a big jumble of DNA into chromosomes while preparing for cell division. For over a century, scientists have been puzzled for decades on how the process works.

It is one of the mysteries in biology: how does a cell neatly distribute its replicated DNA between two daughter cells? Scientists are split into two camps: the first argues that condensing works like ...

How does a meter-long strand of DNA fit inside a cell without forming a tangled mess? This accomplishment comes courtesy of structural maintenance of chromosomes (SMC) proteins, which orchestrate the ...

The paper M. Ganji et al., “Real-time imaging of DNA loop extrusion by condensin,” Science, doi:10.1126/science.aar7831, 2018. How does a human cell neatly pack ...

To separate replicated sister chromatids during mitosis, eukaryotes and prokaryotes have structural maintenance of chromosome (SMC) condensin complexes that were recently shown to organize chromosomes ...

Reproduction and evolution of life – from humans to bacteria – are based on preserving, adapting and passing on genetic information. The genetic material is stored in the form of DNA in almost every ...

A human cell carries in its nucleus two meters of spiraling DNA, split up among the 46 slender, double-helical molecules that are its chromosomes. Most of the time, that DNA looks like a tangled ball ...

DNA loop extrusion is a method used to analyze how DNA is compacted into the nucleus whilst bringing regulatory elements close to protein coding genes. DNA, or deoxyribonucleic acid, is the genetic ...