PTIR calculates the rates at which originally monomeric proteins are transformed into aggregates at various temperatures under initial-rate settings. Utilizing SMSLS for identical conditions generates ...

Researchers have identified a backup mechanism of protein quality control which prevents the toxic effects of protein aggregation in specific tissues when normal methods of molecular monitoring fail.

Yeast prions are increasingly recognised as pivotal agents in non-Mendelian inheritance, whereby protein conformations rather than nucleic acids dictate heritable traits. In Saccharomyces cerevisiae ...

Researchers have used computational models to understand what drives the accumulation of alpha-synuclein protein, a key culprit in the development of Parkinson’s disease. The study, published today as ...

Raghu R. Chivukula, MD, Ph.D., a physician-investigator in the Departments of Medicine & Surgery and the Center for Genomic Medicine at Massachusetts General Hospital and Harvard Medical School, is ...

A chloroplast enzyme safeguards plants against pathological protein aggregation that causes Huntington’s and other neurodegenerative diseases. New research may have found a way to 'copy' the mechanism ...

Micro- and nanoplastics are increasingly detected in human tissues, including the brain, and experimental evidence suggests ...

Back when James Parkinson first described the disorder now known as Parkinson’s disease, he noticed that severe constipation can be a prelude to the signature tremors. In the 208 years since then, ...

A new study from scientists at VIB-KU Leuven Center for Brain & Disease and elsewhere reveals the role of an RNA binding protein called Fused in Sarcoma (FUS) in the development of frontotemporal ...

Northwestern Medicine scientists have zeroed in on a cellular gatekeeper that may hold promise for treating abnormal protein ...

Proteins form the building blocks of life, but when they form unusual clumps inside the brain, they raise an alarm that ...