Making proteins for research or therapies often starts with cell-line development. In many applications, genetic engineering is used to optimize a cell line for producing high levels of the intended ...

Inside every cell, thousands of molecular signals collide, overlap, and compensate, obscuring the true drivers of gene expression. Scientists have now developed a way to silence that cellular noise, ...

Propagation of expression noise from mRNA to protein level is influenced by variation in availability of ribosomal machinery.

The latest short science news items from C&EN. Proteins are vital for life, involved in virtually every biochemical process that makes life possible. They comprise one or more amino acid chains ...

A comprehensive assessment of protein expression product and service providers, along with information on several relevant parameters, such as year of establishment, company size and location of ...

Validogen is launching next-generation synthetic methanol-free promoters, which may lead to “substantially increased productivities.” ...

To enhance CAR T therapies, scientists are actively studying TCR signaling and T-cell exhaustion mechanisms to improve CAR T persistence and function. Additionally, there is a growing trend towards ...

Epigenome editing has followed a similar path, in that more recent technological breakthroughs have enabled scientists to apply the discoveries made in previous decades. Epigenome editing performs a ...

Gene therapy has been successfully used to treat a number of diseases, including immune deficiencies, hereditary blindness, ...