Advancements in spatial proteomics enable detailed tissue mapping, linking protein localization to disease mechanisms and ...

The functioning of neurons, cells that transmit information in the nervous system, heavily relies on the production of ...

Localizatome contains comprehensive information about the stress-induced protein localization changes within living cells. It provides open access to subcellular protein localization data through a ...

CAMBRIDGE, MA – A protein located in the wrong part of a cell can contribute to several diseases, such as Alzheimer’s, cystic fibrosis, and cancer. But there are about 70,000 different proteins and ...

An international team has assembled the first large-scale, publicly available map to show the impact of mutations on where proteins end up in the cell. The team developed a high-throughput imaging ...

The team developed a high-throughput imaging platform to assess the influence of nearly 3,500 mutations on protein location. They found that roughly one in six disease-causing mutations led to ...

Researchers developed a new machine learning method that, given a relevant amino acid sequence, can automatically predict the location of a protein in any human cell line down to the single-cell level ...