At the University of Oxford, scientists have developed a nanopore technology that can identify three different post-translational modifications (PTMs) in individual proteins, even deep within long ...

One of the main goals of proteomics is to unravel the many modifications important for biological activity. Post-translational modifications (PTMs) extend the range of protein function by attaching it ...

Protein AMPylation represents a specialised post‐translational modification (PTM) in which an adenosine monophosphate (AMP) moiety is covalently attached to specific amino acid residues on target ...

Exploring the post-translational modifications of a key protein in Parkinson's disease, researchers uncover potential pathways for future therapies in neurodegenerative diseases in general.

A team of scientists led by the University of Oxford have achieved a significant breakthrough in detecting modifications on protein structures. The method, published in Nature Nanotechnology, employs ...

Whole blood derived from six adult donors who were inoculated with BCG in their childhood was cultured with MDP1 alone, MDP1 in combination with G9.1, or in combination with the negative form of ...

Lactylation, a recently identified post-translational modification, has emerged as important for immune regulation, tissue repair, cancer cell metabolism, and now, potentially, Alzheimer’s disease. In ...

Researchers at Baylor College of Medicine have developed an artificial intelligence (AI) model that reveals how protein modifications link genetic mutations to disease. The method, called DeepMVP and ...

One of the first things that students learn when they enter a biology class is the central dogma: DNA → messenger RNA → proteins. Only about 3% of the human genome directly codes for proteins, which ...

Post-translational modifications (PTMs) play a key role in dynamic cellular processes, regulating gene expression, protein activity, localization, and degradation, as well as protein interaction.

Tuberculosis is still one of the deadliest infectious diseases, causing over one million deaths each year worldwide. Additionally, about one-fourth of the world's population carries Mycobacterium ...