Drug discovery requires two separate steps: checking whether a drug can bind to a harmful molecule or its receptor, and ...

Viruses attack nearly every living organism on Earth. To do so, they rely on highly specialized proteins that recognize and ...

The behaviour of a receptor protein can be influenced by the presence of certain lipids in the membrane it is embedded in.

A research team of the University Medical Center Mainz has succeeded in observing for the first time how G protein-coupled receptors in living cells actually respond to activating substances. The ...

A new study found that a single mutation to the hemagglutinin protein of an H5N1 virus isolated from a dairy worker in Texas this spring switched the protein’s binding specificity from avian- to human ...

The ability to grow stem cell-derived biological tissues, such as skin and other organs, in the laboratory holds promise for applications in areas including wound healing and transplants. However, ...

A new editorial paper was published in Oncoscience, titled "PH-binding motifs as a platform for drug design: Lessons from protease-activated receptors; PARs." While targeted cancer therapy is greatly ...

"To provide direct evidence for binding of the molecule at different pockets of the receptor, we have developed a new assay, which enables us to measure the binding specifically at the extracellular ...

Many people are familiar with histamine, a biological molecule that serves as a key driver of allergic reactions and other immune responses. However, histamine is also a major neurotransmitter in the ...

A new study reveals a critical vulnerability in a brain receptor targeted by a rare autoimmune disease. Researchers have ...