Structured illumination microscopy (SIM) is the most preferable system for live-cell super-resolution imaging. It enables the observation of intricate subcellular dynamics. However, conventional SIM ...

Even those who maintain that super-resolution microscopy is a powerful tool of biological discovery have admitted that it may have a bit of an image problem. For example, in a recent review, several ...

Schematic of the imaging process. Incoherent light, modulated by the DMD, is directed into the microscope and focused onto the sample plane by the objective lens, creating structured illumination for ...

To unravel the complexities of biological phenomena, scientists have long relied on microscopy to visualize the intricate details of their specimens, including tissue architecture, cell morphology, ...

Using artificial intelligence, engineers at the University of California San Diego have developed a new way to watch the ...

This is especially true when studying intricate details beyond the optical resolution limit using structured illumination microscopy (SIM). SIM uses multiple images acquired under structured ...

When single-molecule super-resolution microscopes were first commercialized some 15 years ago, they made headlines for their ability to resolve individual molecules and structures at the nanometer ...

Recent breakthroughs in microscopy are enabling scientists to capture sharper, faster, and more reliable images of live cells and complex 3D samples. Caltech's Digital Defocus Aberration Interference ...

Dual-color live-cell super-resolution imaging of mitochondria (green) and endoplasmic reticulum (magenta). Compared to the standard SN2N method, the proposed Adaptive-SN2N (aSN2N) framework ...

Using a tiny, spherical glass lens sandwiched between two brass plates, the 17th century Dutch microscopist Antonie van Leeuwenhoek was the first to officially describe red blood cells and sperm cells ...