RNAi is mediated by the enzymatic processing of long double-stranded RNA (dsRNA) into short-interfering RNA (siRNA)with sequence homology to the target mRNA. These siRNA molecules associate with a ...

The discovery of RNAi dates back to the 1990s when researchers observed unexpected gene silencing in plants and fungi. In 1998, Andrew Fire and Craig Mello published a groundbreaking study ...

With big pharma signalling interest in novel RNA-targeted approaches, the term “druggable” is being redefined as technology ...

The first reports of antisense RNA activity in eukaryotes were published when the efforts to understand the mechanism of mRNA translation were well underway. At that time, cell-free in vitro ...

This article is part 2 of a series on next-generation mRNA vaccines. The first installment can be read here. The unprecedented speed with which we developed vaccines to help us control and curb the ...

RNA, or ribonucleic acid, is a essential biological molecule that plays a crucial role in various cellular processes. It is a polymeric molecule composed of nucleotides, each containing a ribose sugar ...

The next generation of self-replicating mRNA vaccines could have fewer side effects such as fever, headache and fatigue. This would partly result from the application of artificial intelligence in ...

Research led by Duke University, Durham, has discovered a situation-dependent traffic jam in mRNA translation caused by RNA hairpins leading to higher translation of upstream start codons (uAUGs). In ...

RNA interference (RNAi) is a key biological process that leads to the silencing of gene expression. RNAi can be initiated by a cell in response to pathogenic nucleic acids to bring about a targeted ...

Elevated lipoprotein(a) concentrations are associated with atherosclerotic cardiovascular disease. The safety and efficacy of lepodisiran, an extended-duration, small interfering RNA targeting hepatic ...

Lipoprotein(a) is a presumed risk factor for atherosclerotic cardiovascular disease. Olpasiran is a small interfering RNA that reduces lipoprotein(a) synthesis in the liver. We conducted a randomized, ...