Their overview highlights innovative methods based on B-factor analysis, ancestral sequence reconstruction (ASR), and machine learning (ML), providing tools to design enzymes that withstand high ...

Proteins are among the most studied molecules in biology, yet new research from the University of Göttingen shows they can still hold surprising secrets. Researchers have discovered previously ...

An illustration of an algorithm predicting a protein structure, with digitized blocks on the left becoming ribbons on the right. An illustration of the RoseTTAFold software predicting a protein ...

Overview of protein engineering strategies. Directed evolution mimics natural selection in the laboratory through iterative rounds of mutagenesis and screening. Rational design uses structural and ...