A robust and quantitative map links chromatin modification and gene expression of cells during zebrafish embryogenesis.

Every cell in a body contains the same genetic sequence, yet each cell expresses only a subset of those genes. These cell-specific gene expression patterns, which ensure that a brain cell is different ...

Within the realm of genetic regulation, chromatin modifications such as histone methylation and acetylation play pivotal roles in the transcriptional control of genes. Disruptions in these processes ...

DNA inside the nucleus is not packed as a rigid regular fiber—linker histone H1 dynamically binds and loosely "glues" ...

The human genome is about two meters long, yet it fits inside a nucleus only ~10 micrometers in diameter. A research team led ...

Every cell in your body faces the same engineering puzzle: how to cram roughly two meters of DNA into a nucleus just a few ...

Previously, linker histone H1 was thought to bind stably to nucleosomes and compact chromatin by forming an ordered, “rigid” structure (left). In this study, we show that H1 binds to nucleosomes ...