eLife

The Locomoting State Selectively Amplifies Activity of Sensitizing Neurons in Primary Visual Cortex

This manuscript presents a valuable analysis of how locomotion modulates the activity of different subtypes of cortical neurons in the mouse primary visual cortex, showing that locomotion more ...
pharmaphorum

Pfizer's seeks silver lining in failed C. diff vaccine trial

Pfizer's vaccine for Clostridium difficile (C. diff) looks like it may join a growing list of candidates that have been shelved or delayed, after the shot failed to meet its primary objective in a ...
eLife

Distinct allosteric remodeling of HIV-1 Env dynamics on virions by gp41-directed antibodies reveals two modes of neutralization

HIV-1 envelope glycoprotein (Env), a gp120–gp41 trimer, undergoes coordinated conformational changes that drive membrane fusion and allow immune evasion by transiently concealing ...
pharmaphorum

Nestle bids to take control of Seres’ C diff drug Vowst

Swiss food giant Nestlé has said it wants to take full ownership of Seres Therapeutics’ Vowst microbiome therapy for Clostridiodes difficile infections (CDI), upgrading its current co-marketing ...
IEEE

10.3 A 7GHz Digital PLL with Cascaded Fractional Divider and Pseudo-Differential DTC Achieving -62.1dBc Fractional Spur and 143.7fs Integrated Jitter

Abstract: Modern wireless transceivers and FMCW radar systems are demanding stringent specifications on PLL integrated jitter and spur performance for lower EVM and higher position accuracy. To ...