Generative AI Digest: AI Drawn Into Geopolitics

While Anthropic's dispute with the Pentagon escalated over guardrails on military use, OpenAI LLC struck its own publicized ...

What most LLM apps get wrong about security

When Nandakishore Leburu was building LLM applications at LinkedIn, he learned that the models weren't the problem. The ...
eLife

Serotonergic modulation of motor subspace dynamics drives a sleep-independent quiescent state

The dorsal raphe nucleus (DRN) serotonergic (5-HT) system has been implicated in regulating sleep and motor control; however, its specific role remains controversial. In this study, we found that ...
eLife

Gβγ engages PLCβ3 at multiple sites to reorient and facilitate its activation

EM, biochemical, and cell-based assays to examine how Gβγ interacts with and potentiates PLCβ3. The authors present evidence for multiple Gβγ interaction surfaces and argue that Gβγ primarily enhances ...
AHA/ASA Journals

Targeting Interleukin-8–Mediated Cellular Crosstalk Reverses Hypertrophic Cardiomyopathy and Cardiac Fibrosis in Noonan Syndrome

BACKGROUND: Genetic variants in components or regulators of the RAS-MAPK signaling pathway are causative for severe and early-onset hypertrophic cardiomyopathy (HCM) in patients with Noonan syndrome ...