The 'Learn to Code' era is over — as an AI editor, here's the 'Intent Architecture' roadmap I’m giving my kids instead

Coding is becoming a background task. Discover why the "syntax barrier" has vanished and the three orchestration skills I’m ...

The 'learn to code' era is officially over: Why I switched my kids to 'intent architecture' instead

As AI agents move from writing snippets to building entire systems, the $100k skill of the last decade is becoming a ...

POP NOTES | OPINION: Summer season cinema

Once upon a time, summer was a season. Now it’s a land grab, swallowing April, squatting on August, poking at September.
eLife

Molidustat Targets a Synthetic Lethal Vulnerability in APC-Mutant Colorectal Cancer through GSTP1 and PHD2 Co-Inhibition

This important paper substantially advances our understanding of how Molidustat may work, beyond its canonical role, by identifying its therapeutic targets in cancer. This study presents a compelling ...
eLife

Serotonergic modulation of motor subspace dynamics drives a sleep-independent quiescent state

The dorsal raphe nucleus (DRN) serotonergic (5-HT) system has been implicated in regulating sleep and motor control; however, its specific role remains controversial. In this study, we found that ...
AHA/ASA Journals

Targeting Interleukin-8–Mediated Cellular Crosstalk Reverses Hypertrophic Cardiomyopathy and Cardiac Fibrosis in Noonan Syndrome

BACKGROUND: Genetic variants in components or regulators of the RAS-MAPK signaling pathway are causative for severe and early-onset hypertrophic cardiomyopathy (HCM) in patients with Noonan syndrome ...