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Multiple myeloma is a cancer of plasma cells that attacks bone from the inside out. In the skull, it creates classic “punched-out” lytic lesions, round holes where bone has been resorbed without repair. As malignant cells crowd the marrow, they stimulate osteoclasts and suppress bone formation, leaving the cranium fragile, porous, and prone to fracture. This skull shows how systemic disease can dramatically reshape bone. | The Bone Museum
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