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Let’s zoom into what’s actually happening in the liver. The researchers used cutting-edge techniques called transcriptomics and lipidomics – essentially reading out every gene being expressed and every fat molecule present in liver tissue. The high-fat diet had completely scrambled the liver’s metabolic programming. Genes involved in fat storage were cranked up. Genes responsible for glucose metabolism were disregulated. The liver had essentially shifted into a pathological state where it was ho
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